Objective
The goal of this study was to determine the efficacy of prolotherapy in relieving the pain of patients with tendon or ligament laxity.

Method
The subjects were 67 patients (40 male, 27 female) who were suffering from chronic musculoskeletal pain, excluding those with metabolic diseases that could influence the nature of the pain. The effect of the treatment was evaluated by checking the VAS score after a monthly injection of 15% dextrose solution injected around the patient's ligaments and teno-osseous junction that were suspicious of laxity. This same procedure was followed after a second injection. To make an accurate evaluation before and after the treatment, the use of NSAID, physical therapy or exercise therapy was prohibited.

Results
The mean pain duration of the subjects was 5.48⁑7.04 years, and the mean age of the subjects was 49.58⁑16.52 years. The result from VAS showed a statistically remarkable reduction after the injection (p＜0.01). The VAS decreased from 7.00⁑0.17 to 4.31⁑0.21 after the first injection and this score further decreased to 2.55⁑0.19 after the second injection. There was no statistically significant relationship between the duration of pain and the effect of the treatment (p＞0.05).

Conclusion
This research demonstrated that prolotherapy is an effective method in treating patients with chronic musculoskeletal pain caused by tendon or ligament relaxation.