Method
Fifty female rats (Sprague-Dawley strain; BW 210∼260 g, 12∼15 week old) were used: control group; cisplatin group; cisplatin-nimodipine 2 week group, 10; ciplatin-nimodipine 4 week group; base group. Peripheral neuropathy was induced by intraperitoneal injection of the cisplatin (0.04 mg/ml, 1 ml/kg/ip/ for 2 weeks). Nimodipine was injected intraperitoneally for 2 weeks and 4 weeks in cisplatin-nimodipine 2 week group and cisplatin-nimodipine 4 week group, respectively. Motor and sensory nerve conduction studies were done using in rat tail nerve from the beginning and biweekly till to 10^th week.

Results
Weight reduction was significant in cisplatin group at 2^nd week (p＜0.05). The latencies of motor and sensory nerves were delayed in 2^nd, 4^th week in all groups with cisplatin (p＜0.05) and the recovered after 6^th week in all groups. The amplitudes of motor and sensory nerves in these groups haven't made any difference compared with control group (p＞0.05).

Conclusion
The neurotoxicity of cisplatin revealed in motor and sensory neurons. The neuropathy has recovered to control value in 6^th week and the preventive effect of nimodipine was transient. (J Korean Acad Rehab Med 2003; 27: 90-95)