| Effects of Enriched Environment on Locomotion and Cognition in Neonatal Rats with Hypoxic-Ischemic Encephalopathy. |
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Yang, Shin Seung , Sohn, Min Kyun , Kim, Bong Ok , Choi, Pil Soon , Kim, Sung Gyum |
1Department of Rehabilitation Medicine, College of Medicine, Brain Research Institute, Chungnam National University, Korea. mksohn@cnu.ac.kr
2Sun-lin Rehabilitation Hospital, Korea. |
| 저산소 뇌허혈 백서에서 풍요한 환경이 운동과 인지 발달에 미치는 영향 |
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양신승1, 손민균, 김봉옥, 최필순, 김성겸 |
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충남대학교 의과대학 재활의학교실, 뇌과학연구소, 1선린재활요양병원 |
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| Abstract |
Objective
To investigate the effect of environmental enrichment on the cognitive and motor development in the experimental hypoxia-ischemic encephalopathy neonatal rat model.
Method
Hypoxic-ischemic encephalopathy models were made in neonatal Sprague-Dawley rats at 3 days of age by ligating the unilateral carotid artery followed by inhalation of 8% oxygen and raised in the enriched environment (n=10), treadmill exercise (n=8) and non-stimulation (n=10) from the 3rd to 8th weeks of age. Neurobehavioral and histopathological changes were compared.
Results
The neurobehavioral tests of the rats with hypoxic- ischemic encephalopathy showed prolonged latencies of achievement for cliff avoidance and negative geotaxis (p＜0.05). Persisting abnormality into adult life of limb placing improved in exercise and enriched environment groups and spatial learning and memory in a water maze recovered in the rats with enriched environment (p＜0.05). The density of dendritic spine increased in the hippocampus with enriched environment (p＜0.05).
Conclusion
The present study supports the possibilities of the positive effects after the enriched environment in the developing brain with hypoxic injury. (J Korean Acad Rehab Med 2010; 34: 1-9) |
| Key Words:
Enriched environment, Hypoxic-ischemic encephalopathy, Neonate, Rat |
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